Pharmaceutical cream is a semisolid dosage form either the oil-in-water or water-in-oil type. It may also contain one or more drug substances dissolved or dispersed in a suitable cream base. Here we mention a list of common excipients used in the cream preparation with recommended percentage.
A List of Excipients Used in Cream Preparation
• Acacia – 10 to 20% (as an emulsifying agent)
• Alcohol – 60 to 90% (as a solvent in topical formulation)
• Alpha Tocopherol – 0.001 to 0.05% v/v (as an antioxidant)
• Ascorbic Acid – 0.01 to 0.1% w/v (as an antioxidant)
• Bentonite – 1% (as an emulsion stabilizer)
• Benzoic Acid – 0.1 to 0.2% (as an antimicrobial preservative)
• Butylated Hydroxyanisole – up to 0.02% w/w (as an antioxidant)
• Butylated hydroxytoluene - up to 0.1% w/w (as an antioxidant)
• Butylparaben – 0.02% to 0.4% (as an antimicrobial preservative)
• Cetostearyl Alcohol – amount may vary (as an emulsifying agent)
• Cetyl alcohol – 2 to 5% (as an emulsifying agent or emollient)
• Chlorocresol – 0.075 to 0.2% (as an antimicrobial preservative)
• Citric Acid Monohydrate – amount may vary (as an acidifying agent)
• Glycerin – up to 30% (as an emollient)
• Isopropyl alcohol – amount may vary (as a solvent)
• Isopropyl myristate – 1 to 10% (as an emollient or oleaginous vehicle)
• Isopropyl palmitate – 0.05 to 5.5% (as an emollient or oleaginous vehicle)
• Lactic acid – 0.015 to 6.6% (as an acidifying agent)
• Lanolin – amount may vary (as a hydrophobic vehicle)
• Linoleic Acid - amount may vary (as an emulsifying agent)
• Methyllparaben – 0.02 to 0.3% (as an antimicrobial preservative)
• Mineral oil – 1 to 32% (as an emollient)
• Myristic acid – amount may vary (as an emulsifying agent or skin penetrant)
• Myristyl alcohol - amount may vary (as an emulsifying agent or skin penetrant)
• Oleic acid - amount may vary (as an emulsifying agent or skin penetrant)
• Palmitic acid - amount may vary (as an emulsifying agent or skin penetrant)
• Paraffin - amount may vary (as an ointment base)
• Poloxamer – 0.01 to 5% (as a wetting agent)
• Polyethylene glycol - amount may vary (as an ointment base)
• Propylene glycol – around 15% (as a humectant)
• Propylene glycol – 15 to 30% (as a preservative)
• Propylparaben – 0.01 to 0.6% (as an antimicrobial preservative)
• Sorbic acid – 0.05 to 0.2 5 (as an antimicrobial preservative)
• Stearyl alcohol – amount may vary (as a stiffening agent)
• Thimerosal – 0.01% (as an antimicrobial preservative)
• Triolein - amount may vary (as an emollient or penetration enhancer)
• Wax, Anionic Emulsifying – up to 10% (as an emulsifying agent)
• Wax, Cetyl Esters – 1 to 15% (as an emulsifying or stiffening agent)
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